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ENZYMEDefinition: sourced draft

CYP2A6

An enzyme with an important role in nicotine metabolism.

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Claim · not formally assessed

CYP2A6 contributes to nicotine metabolism.

Route-dependent human nicotine pharmacokinetics.

Source

Limitation CYP2A6 metabolism does not make nicotine a proxy for tobacco-smoke induction of CYP1A2.

Nicotine · Sourced draft
metabolic pathway

Nicotine metabolism

Nicotine and caffeine have distinct major metabolic pathways; nicotine is not a proxy for tobacco smoke induction of CYP1A2.

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Linked substances

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Stimulant

Nicotine

An addictive nicotinic acetylcholine receptor agonist. Delivery route changes exposure; tobacco-smoke harms and nicotine pharmacology need separate treatment.

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Definition sources

Supporting reading for this original editorial definition. Independent editorial review has not been recorded.

Observation & claim sources

  1. Pharmacology review · 2009

    Nicotine chemistry, metabolism, kinetics and biomarkers

    Benowitz, Hukkanen & Jacob

    Describes route-dependent absorption, elimination and metabolic modifiers.

    Limitation Population summaries differ by product and exposure history; a plasma half-life is not a duration-of-effect estimate.

    Funding / disclosures Not assessed; consult the original disclosure.

    Source in Nicotine