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Explore substances, mechanisms, and effects. Select a node to read its article and inspect the evidence.
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Substances
Concepts
- Psychedelicclass
- Serotoninneurotransmitter
- Altered perceptioneffect
- Depression symptom severityoutcome
- Clinical psychological supportexposure
Relationships
Editorial index: substances classified under psychedelic. This index does not assert a combined effect. Compounds that can produce substantial changes in perception and experience.
- Psychedelicindex concept
- Psilocybinindexed substance
Editorial index: substances classified under serotonin 5-ht2a receptor. This index does not assert a combined effect. A serotonin receptor implicated by human antagonist experiments in acute psilocybin effects.
- Serotonin 5-HT2A receptorindex concept
- Psilocybinindexed substance
Editorial index: substances classified under serotonin. This index does not assert a combined effect. A transmitter with multiple receptor families; receptor activity is not a benefit score.
- Serotoninindex concept
- Psilocybinindexed substance
Editorial index: substances classified under altered perception. This index does not assert a combined effect. Changes in the character of sensory experience.
- Altered perceptionindex concept
- Psilocybinindexed substance
Editorial index: substances classified under us federal schedule i. This index does not assert a combined effect. A US federal classification; not a worldwide or state-level legal conclusion.
- US federal Schedule Iindex concept
- Psilocybinindexed substance
Editorial index: substances classified under depression symptom severity. This index does not assert a combined effect. Severity measured with a specified clinical instrument, population and follow-up interval; a scale change does not by itself establish remission.
- Depression symptom severityindex concept
- Psilocybinindexed substance
Editorial index: substances classified under clinical psychological support. This index does not assert a combined effect. Preparation and support supplied within a clinical research protocol. Findings from that setting do not establish outcomes of unsupervised exposure.
- Clinical psychological supportindex concept
- Psilocybinindexed substance
Human antagonist studies link acute psilocybin effects to serotonin receptor signaling.
- Psychedelicfunctional-class
- Serotonin 5-HT2A receptortarget
- Serotoninendogenous-ligand
- Altered perceptionsubjective-effect
- Psilocybinadministered-prodrug
The higher-dose study arm reduced depression severity relative to the low-dose control at the primary time point. Treatment-resistant depression; standardized preparation and psychological support; assessment at week 3.
- Depression symptom severitymeasured-outcome
- Clinical psychological supportco-intervention
- Psilocybinexposure
A scoped federal classification with an authority source; no inference about other jurisdictions.
- US federal Schedule Ijurisdictional-classification
- Psilocybinclassified-compound
Relationship nodes connect multiple concepts in one sourced statement. Member roles identify the substance, biological target, measured outcome, or exposure context. Editorial index relationships group classifications. Connections are not recommendations to combine substances.