The knowledge graph.
Explore substances, mechanisms, and effects. Select a node to read its article and inspect the evidence.
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Substances
Concepts
- Acetylcholineneurotransmitter
- Histamineneurotransmitter
- Histamine H1 receptortarget
- Drowsinesseffect
- Antihistamineclass
- Age contextexposure
Relationships
Editorial index: substances classified under acetylcholine. This index does not assert a combined effect. The endogenous transmitter at nicotinic and muscarinic receptors.
- Acetylcholineindex concept
- Diphenhydramineindexed substance
Editorial index: substances classified under histamine. This index does not assert a combined effect. A signaling molecule acting at histamine receptors; effects depend on receptor and tissue.
- Histamineindex concept
- Diphenhydramineindexed substance
Editorial index: substances classified under histamine h1 receptor. This index does not assert a combined effect. A histamine receptor targeted by H1 antihistamines; distinguish it from muscarinic receptor activity.
- Histamine H1 receptorindex concept
- Diphenhydramineindexed substance
Editorial index: substances classified under muscarinic acetylcholine receptors. This index does not assert a combined effect. An acetylcholine receptor family distinct from nicotinic receptors. Antagonism can reduce secretions and produce other anticholinergic effects.
- Muscarinic acetylcholine receptorsindex concept
- Diphenhydramineindexed substance
Editorial index: substances classified under drowsiness. This index does not assert a combined effect. A subjective tendency toward sleep. Reports of drowsiness and laboratory performance can diverge.
- Drowsinessindex concept
- Diphenhydramineindexed substance
Editorial index: substances classified under antihistamine. This index does not assert a combined effect. Compounds that inhibit histamine receptor signaling. Receptor selectivity and additional actions differ across drugs.
- Antihistamineindex concept
- Diphenhydramineindexed substance
Editorial index: substances classified under age context. This index does not assert a combined effect. Age-defined study groups can differ in drug disposition. Age associations need study-specific interpretation.
- Age contextindex concept
- Diphenhydramineindexed substance
Age-group differences in one syrup study were not replicated in a lower-exposure experiment; no universal age multiplier is assigned.
- Age contextpopulation-context
- Diphenhydraminesubstance
Swine airway-cell assay; the result does not quantify human cognitive effects.
- Acetylcholinetransmitter
- Muscarinic acetylcholine receptorstarget
- Diphenhydraminesubstance
H1 antihistamine activity is distinct from the compound's antimuscarinic actions.
- Histaminetransmitter
- Histamine H1 receptortarget
- Diphenhydraminesubstance
Relationship nodes connect multiple concepts in one sourced statement. Member roles identify the substance, biological target, measured outcome, or exposure context. Editorial index relationships group classifications. Connections are not recommendations to combine substances.