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Explore substances, mechanisms, and effects. Select a node to read its article and inspect the evidence.
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Substances
Concepts
- Depression symptom severityoutcome
- Clinical psychological supportexposure
Relationships
Editorial index: substances classified under depression symptom severity. This index does not assert a combined effect. Severity measured with a specified clinical instrument, population and follow-up interval; a scale change does not by itself establish remission.
- Depression symptom severityindex concept
- Psilocybinindexed substance
Editorial index: substances classified under clinical psychological support. This index does not assert a combined effect. Preparation and support supplied within a clinical research protocol. Findings from that setting do not establish outcomes of unsupervised exposure.
- Clinical psychological supportindex concept
- Psilocybinindexed substance
The higher-dose study arm reduced depression severity relative to the low-dose control at the primary time point. Treatment-resistant depression; standardized preparation and psychological support; assessment at week 3.
- Depression symptom severitymeasured-outcome
- Clinical psychological supportco-intervention
- Psilocybinexposure
Relationship nodes connect multiple concepts in one sourced statement. Member roles identify the substance, biological target, measured outcome, or exposure context. Editorial index relationships group classifications. Connections are not recommendations to combine substances.