MECHANISMDefinition: sourced draft

Adenosine antagonist

Blocks adenosine receptor signaling.

Mechanistic context

Caffeine · Sourced draft

Adenosine receptor antagonism

Caffeine interferes with adenosine signaling. Feeling less sleepy does not mean the underlying need for sleep has disappeared. Source

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Connections & claims

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Linked substances

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Tagged articles and participants in the relationships above. A shared tag alone does not establish a causal effect.

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Definition sources

Supporting reading for this original editorial definition. Independent editorial review has not been recorded.

Observation & claim sources

  1. Narrative review · 2017

    The Safety of Ingested Caffeine: A Comprehensive Review

    Temple et al.

    Reviews absorption, adenosine signaling, adult elimination and population-specific safety concerns.

    Limitation A broad review; its typical kinetic values cannot predict an individual's response.

    Funding / disclosures Not assessed; consult the original disclosure.

    Source in Caffeine