EXPOSURE CONTEXTDefinition: sourced draft

Age context

Age-defined study groups can differ in drug disposition. Age associations need study-specific interpretation.

Connections & claims

Open graph

Each relationship keeps its participants and their roles together. Source details explain what the connection supports.

Linked substances

2 entries

Tagged articles and participants in the relationships above. A shared tag alone does not establish a causal effect.

Follow the sources

Definition sources

Supporting reading for this original editorial definition. Independent editorial review has not been recorded.

Observation & claim sources

  1. Human pharmacokinetic study · 1990

    Diphenhydramine: pharmacokinetics and pharmacodynamics in elderly adults, young adults, and children

    Simons et al.

    Compared serum elimination and skin-test responses across age groups.

    Limitation Small groups and a particular syrup exposure; group means do not predict individual clearance.

    Funding / disclosures Not assessed in this draft.

    Source in Diphenhydramine
  2. Randomized placebo-controlled crossover study · 1998

    Pharmacokinetics and pharmacodynamics of diphenhydramine 25 mg in young and elderly volunteers

    Scavone et al.

    Did not detect significant age effects on kinetics or sedation differences at the tested exposure.

    Limitation An undetected difference in one acute experiment does not establish absence of impairment in other settings.

    Funding / disclosures NIMH support is listed in the PubMed record; other funding not assessed.

    Source in Diphenhydramine