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Explore substances, mechanisms, and effects. Select a node to read its article and inspect the evidence.
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Substances
Concepts
- Stimulantclass
- Nicotinic agonistmechanism
- Acetylcholineneurotransmitter
Relationships
Editorial index: substances classified under stimulant. This index does not assert a combined effect. Compounds associated with increased arousal; mechanisms and risks differ.
Source 1 ↗Source 2 ↗Editorial index: substances classified under nicotinic agonist. This index does not assert a combined effect. Activates nicotinic acetylcholine receptors.
- Nicotinic agonistindex concept
- Nicotineindexed substance
Editorial index: substances classified under acetylcholine. This index does not assert a combined effect. The endogenous transmitter at nicotinic and muscarinic receptors.
- Acetylcholineindex concept
- Nicotineindexed substance
- Diphenhydramineindexed substance
Editorial index: substances classified under nicotinic acetylcholine receptors. This index does not assert a combined effect. Ligand-gated receptors activated by acetylcholine and nicotine. Receptor subtypes and desensitization affect the response.
- Nicotinic acetylcholine receptorsindex concept
- Nicotineindexed substance
Editorial index: substances classified under muscarinic acetylcholine receptors. This index does not assert a combined effect. An acetylcholine receptor family distinct from nicotinic receptors. Antagonism can reduce secretions and produce other anticholinergic effects.
- Muscarinic acetylcholine receptorsindex concept
- Diphenhydramineindexed substance
Swine airway-cell assay; the result does not quantify human cognitive effects.
- Acetylcholinetransmitter
- Muscarinic acetylcholine receptorstarget
- Diphenhydraminesubstance
Nicotine acts at nicotinic acetylcholine receptors; dependence is integral to the interpretation.
- Stimulantfunctional-class
- Nicotinic agonistmechanism
- Acetylcholineendogenous-ligand
- Nicotinic acetylcholine receptorstarget
- Nicotineagent
Relationship nodes connect multiple concepts in one sourced statement. Member roles identify the substance, biological target, measured outcome, or exposure context. Editorial index relationships group classifications. Connections are not recommendations to combine substances.