The endogenous transmitter at nicotinic and muscarinic receptors.
Each relationship keeps its participants and their roles together. Source details explain what the connection supports.
Cultured swine airway mucus-gland cells
Limitation Preclinical tissue assay; it does not quantify human cognitive effects.
Diphenhydramine · Sourced draftReceptor pharmacology in a clinical review of dependence.
Limitation Dependence and withdrawal confound claims of enhancement.
Nicotine · Sourced draftSwine airway-cell assay; the result does not quantify human cognitive effects.
Nicotine acts at nicotinic acetylcholine receptors; dependence is integral to the interpretation.
Tagged articles and participants in the relationships above. A shared tag alone does not establish a causal effect.
An H1 antihistamine with antimuscarinic and sedative actions. A sedating experience is not equivalent to restorative sleep or preserved performance.
Sourced draftStimulantAn addictive nicotinic acetylcholine receptor agonist. Delivery route changes exposure; tobacco-smoke harms and nicotine pharmacology need separate treatment.
Sourced draftSupporting reading for this original editorial definition. Independent editorial review has not been recorded.
Compared antihistamine and antimuscarinic actions in airway cells.
Limitation Swine cell preparation; cannot determine human clinical benefit or harm magnitude.
Funding / disclosures Not assessed in this draft.
Source in DiphenhydramineExplains receptor signaling, reinforcement and the cycle of dependence and withdrawal.
Limitation Not a trial of nicotine enhancement in people who do not use tobacco.
Funding / disclosures Not assessed; consult the original disclosure.
Source in Nicotine