Serotonin 5-HT2A signaling
Blocking this receptor attenuated acute psilocybin effects in a human experiment. That does not establish a complete mechanism for lasting therapeutic change. Source
Read the substance articleBIOLOGICAL TARGETDefinition: sourced draft
Serotonin 5-HT2A receptor
A serotonin receptor implicated by human antagonist experiments in acute psilocybin effects.
Also called 5-HT2A, HTR2A
Mechanistic context
Connections & claims
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Antagonist experiments support serotonin 5-HT2A involvement in acute psilocybin effects.
Controlled acute human antagonist experiment.
- Psilocybinadministered-prodrug
- Serotonin 5-HT2A receptortarget
- Altered perceptionsubjective-effect
Limitation Acute receptor evidence does not establish a complete mechanism of sustained therapeutic change.
Psilocybin · Sourced draftSerotonin and perception
Human antagonist studies link acute psilocybin effects to serotonin receptor signaling.
- Psychedelicfunctional-class
- Serotonin 5-HT2A receptortarget
- Serotoninendogenous-ligand
- Altered perceptionsubjective-effect
- Psilocybinadministered-prodrug
Linked substances
1 entriesTagged articles and participants in the relationships above. A shared tag alone does not establish a causal effect.
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Definition sources
Supporting reading for this original editorial definition. Independent editorial review has not been recorded.
Observation & claim sources
- Human antagonist experiment · 1998
Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action
Antagonist pretreatment supported a role for serotonin receptors in acute effects.
Limitation Historical terminology and an acute laboratory experiment do not establish a model of schizophrenia or a therapeutic mechanism.
Funding / disclosures Not assessed; consult the original disclosure.
Source in Psilocybin