SUBJECTIVE EFFECTDefinition: sourced draft
Altered perception
Changes in the character of sensory experience.
Reported experience
1 observationsThese qualitative descriptions preserve the reported direction and setting. They do not assign a universal intensity score.
Perceptual alteration
Human antagonist experiments support serotonin-receptor involvement in changes to perception and experience; no intensity score is assigned. Source
- Evidence type
- Human research
- Population
- Healthy volunteers in an acute antagonist experiment
- Exposure
- Psilocybin with pharmacological pretreatment in a controlled setting
- Instrument
- Acute subjective assessment; exact scale not assessed
- Reported magnitude
- Not established
Each relationship keeps its participants and their roles together. Source details explain what the connection supports.
Claim · not formally assessedAntagonist experiments support serotonin 5-HT2A involvement in acute psilocybin effects.
Controlled acute human antagonist experiment.
Limitation Acute receptor evidence does not establish a complete mechanism of sustained therapeutic change.
Psilocybin · Sourced draft receptor pathwaySerotonin and perception
Human antagonist studies link acute psilocybin effects to serotonin receptor signaling.
Linked substances
1 entriesTagged articles and participants in the relationships above. A shared tag alone does not establish a causal effect.
Follow the sources
Definition sources
Supporting reading for this original editorial definition. Independent editorial review has not been recorded.
Observation & claim sources
- Human antagonist experiment · 1998Vollenweider et al.
Antagonist pretreatment supported a role for serotonin receptors in acute effects.
Limitation Historical terminology and an acute laboratory experiment do not establish a model of schizophrenia or a therapeutic mechanism.
Funding / disclosures Not assessed; consult the original disclosure.
Source in Psilocybin