Nicotinic acetylcholine receptors
Receptor activation changes neurotransmitter release, including dopamine signaling involved in reinforcement. Source
Read the substance articleBIOLOGICAL TARGETDefinition: sourced draft
Nicotinic acetylcholine receptors
Ligand-gated receptors activated by acetylcholine and nicotine. Receptor subtypes and desensitization affect the response.
Also called nAChR
Mechanistic context
Connections & claims
Open graphEach relationship keeps its participants and their roles together. Source details explain what the connection supports.
Nicotine activates nicotinic acetylcholine receptors.
Receptor pharmacology in a clinical review of dependence.
- Nicotineagent
- Nicotinic acetylcholine receptorstarget
- Acetylcholineendogenous-ligand
Limitation Dependence and withdrawal confound claims of enhancement.
Nicotine · Sourced draftCholinergic signaling
Nicotine acts at nicotinic acetylcholine receptors; dependence is integral to the interpretation.
- Stimulantfunctional-class
- Nicotinic agonistmechanism
- Acetylcholineendogenous-ligand
- Nicotinic acetylcholine receptorstarget
- Nicotineagent
Linked substances
1 entriesTagged articles and participants in the relationships above. A shared tag alone does not establish a causal effect.
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Definition sources
Supporting reading for this original editorial definition. Independent editorial review has not been recorded.
Observation & claim sources
- Clinical review · 2010
Nicotine addiction
Explains receptor signaling, reinforcement and the cycle of dependence and withdrawal.
Limitation Not a trial of nicotine enhancement in people who do not use tobacco.
Funding / disclosures Not assessed; consult the original disclosure.
Source in Nicotine