Antimuscarinic activity
Experimental inhibition of acetylcholine-driven secretion supports a distinct antimuscarinic mechanism. Source
Read the substance articleBIOLOGICAL TARGETDefinition: sourced draft
Muscarinic acetylcholine receptors
An acetylcholine receptor family distinct from nicotinic receptors. Antagonism can reduce secretions and produce other anticholinergic effects.
Mechanistic context
Connections & claims
Open graphEach relationship keeps its participants and their roles together. Source details explain what the connection supports.
Diphenhydramine inhibited muscarinic signaling in an airway-cell experiment.
Cultured swine airway mucus-gland cells
- Diphenhydraminesubstance
- Muscarinic acetylcholine receptorstarget
- Acetylcholinetransmitter
Limitation Preclinical tissue assay; it does not quantify human cognitive effects.
Diphenhydramine · Sourced draftAntimuscarinic activity in an airway assay
Swine airway-cell assay; the result does not quantify human cognitive effects.
- Acetylcholinetransmitter
- Muscarinic acetylcholine receptorstarget
- Diphenhydraminesubstance
Linked substances
1 entriesTagged articles and participants in the relationships above. A shared tag alone does not establish a causal effect.
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Definition sources
Supporting reading for this original editorial definition. Independent editorial review has not been recorded.
Observation & claim sources
- Preclinical receptor-function experiment · 2005
Effects of first and second generation antihistamines on muscarinic induced mucus gland cell ion transport
Compared antihistamine and antimuscarinic actions in airway cells.
Limitation Swine cell preparation; cannot determine human clinical benefit or harm magnitude.
Funding / disclosures Not assessed in this draft.
Source in Diphenhydramine