Contribute
BIOLOGICAL TARGETDefinition: sourced draft

Histamine H1 receptor

A histamine receptor targeted by H1 antihistamines; distinguish it from muscarinic receptor activity.

1 definition sourcesExplore connections

Mechanistic context

Diphenhydramine · Sourced draft

H1 antihistamine activity

Diphenhydramine inhibits histamine-mediated responses; its additional muscarinic activity makes it pharmacologically broader than an H1-only description. Source

Read the substance article

Connections & claims

Open graph

Each relationship keeps its participants and their roles together. Source details explain what the connection supports.

Linked substances

1 entries

Tagged articles and participants in the relationships above. A shared tag alone does not establish a causal effect.

Antihistamine

Diphenhydramine

An H1 antihistamine with antimuscarinic and sedative actions. A sedating experience is not equivalent to restorative sleep or preserved performance.

Sourced draft

Follow the sources

Definition sources

Supporting reading for this original editorial definition. Independent editorial review has not been recorded.

Observation & claim sources

  1. Preclinical receptor-function experiment · 2005

    Effects of first and second generation antihistamines on muscarinic induced mucus gland cell ion transport

    Liu et al.

    Compared antihistamine and antimuscarinic actions in airway cells.

    Limitation Swine cell preparation; cannot determine human clinical benefit or harm magnitude.

    Funding / disclosures Not assessed in this draft.

    Source in Diphenhydramine