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MEASURED OUTCOMEDefinition: sourced draft

Depression symptom severity

Severity measured with a specified clinical instrument, population and follow-up interval; a scale change does not by itself establish remission.

1 definition sourcesExplore connections

Findings in context

1 observations

Measured endpoints are tied to a particular task, population, and exposure. A finding cannot be generalized to a different outcome without supporting evidence.

PsilocybinSourced draft
Decreased

Depression symptom severity

The studied higher-dose arm improved the primary short-term outcome compared with the low-dose control, with adverse events and unresolved durability. Source

Evidence type
Human research
Population
Adults with treatment-resistant depression in the phase 2 trial
Exposure
Single 25 mg psilocybin administration with psychological support versus 1 mg control; week 3
Instrument
Montgomery–Åsberg Depression Rating Scale (MADRS)
Reported magnitude
Not established

Connections & claims

Open graph

Each relationship keeps its participants and their roles together. Source details explain what the connection supports.

Linked substances

1 entries

Tagged articles and participants in the relationships above. A shared tag alone does not establish a causal effect.

Psychedelic

Psilocybin

A prodrug of psilocin, studied in supported clinical settings. Subjective effects, therapeutic outcomes and legal status are distinct questions.

Sourced draft

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Definition sources

Supporting reading for this original editorial definition. Independent editorial review has not been recorded.

Observation & claim sources

  1. Phase 2 randomized trial · 2022

    Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression

    Goodwin et al.

    A supported clinical protocol improved the primary short-term depression outcome in the higher-dose arm.

    Limitation Adverse events occurred; longer and comparative trials are needed. Funded by COMPASS Pathfinder.

    Funding / disclosures COMPASS Pathfinder.

    Source in Psilocybin