MEASURED OUTCOMEDefinition: sourced draft

Stroke recovery

Functional and neurological recovery after stroke, measured using specified clinical scales and follow-up.

Findings in context

1 observations

Measured endpoints are tied to a particular task, population, and exposure. A finding cannot be generalized to a different outcome without supporting evidence.

CiticolineSourced draft
Variable

Global recovery after stroke

ICTUS found no significant recovery advantage over placebo and was stopped for futility. Source

Evidence type
Human research
Population
Adults with moderate-to-severe acute ischemic stroke
Exposure
Hospital trial: intravenous followed by oral citicoline
Instrument
Global endpoint combining NIHSS, modified Rankin Scale and Barthel Index at 90 days
Reported magnitude
Odds ratio 1.03; 95% CI 0.86–1.25

Connections & claims

Open graph

Each relationship keeps its participants and their roles together. Source details explain what the connection supports.

No sourced relationships have been assessed for this concept yet.

Linked substances

1 entries

Tagged articles and participants in the relationships above. A shared tag alone does not establish a causal effect.

Follow the sources

Definition sources

Supporting reading for this original editorial definition. Independent editorial review has not been recorded.

Observation & claim sources

  1. Multicentre randomized placebo-controlled trial · 2012

    Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial)

    Dávalos et al.

    Did not demonstrate a recovery advantage in moderate-to-severe acute ischemic stroke.

    Limitation A clinical stroke population and hospital treatment sequence; findings do not resolve healthy-memory questions.

    Funding / disclosures Ferrer Grupo.

    Source in Citicoline