Dopamine transporter blockade
Human PET detected dose-dependent transporter occupancy after oral administration. Source
Read the substance articleBIOLOGICAL TARGETDefinition: sourced draft
Dopamine transporter
A membrane transporter involved in dopamine reuptake. Human PET studies can measure occupancy without establishing general cognitive benefit.
Also called DAT
Mechanistic context
Dopamine transporter interaction
PET measurements support transporter occupancy and altered extracellular dopamine in the studied men. Source
Read the substance articleConnections & claims
Open graphEach relationship keeps its participants and their roles together. Source details explain what the connection supports.
Oral methylphenidate occupied dopamine transporters in a PET study.
Acute exposure in healthy volunteers
- Methylphenidatesubstance
- Dopamine transportertarget
- Dopaminetransmitter
Limitation Mechanistic imaging does not measure clinical response.
Methylphenidate · Sourced draftModafinil occupied dopamine transporters in a human imaging experiment.
Healthy male participants in an acute PET experiment
- Modafinilsubstance
- Dopamine transportertarget
- Dopaminetransmitter
Limitation Target occupancy is not a clinical outcome and the selected sample limits generalization.
Modafinil · Sourced draftMethylphenidate and dopamine transport
Oral administration produced transporter occupancy in a human PET study.
- Dopamine transportertarget
- Dopaminetransmitter
- Methylphenidatesubstance
Modafinil and dopamine transport
Acute PET findings in healthy men; target occupancy is distinct from a clinical outcome.
- Dopamine transportertarget
- Dopaminetransmitter
- Modafinilsubstance
Linked substances
2 entriesTagged articles and participants in the relationships above. A shared tag alone does not establish a causal effect.
Stimulant medicine
Methylphenidate
A stimulant medicine with formulation-dependent delivery. ADHD treatment findings and attention-task results should retain their population and exposure context.
Sourced draftWake-promoting medicineModafinil
A wake-promoting medicine studied in diagnosed sleep disorders. Measured wakefulness, felt alertness and everyday performance are different outcomes.
Sourced draftFollow the sources
Definition sources
Supporting reading for this original editorial definition. Independent editorial review has not been recorded.
Observation & claim sources
- Human PET study · 1998
Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate
Directly measured dopamine transporter occupancy after oral methylphenidate.
Limitation Small selected sample and a mechanistic endpoint.
Funding / disclosures Not assessed in this draft.
Source in Methylphenidate - Human PET study · 2009
Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications
Measured dopamine transporter occupancy and changes in extracellular dopamine.
Limitation Small male-only mechanistic study; cannot establish general cognitive efficacy.
Funding / disclosures NIH and other research support listed in the publication record.
Source in Modafinil